| I graduated from King’s College London in 1987 and then moved slightly up the river to study for a PhD in the field of cardioplegic protection under the supervision of David Hearse at St. Thomas’ Hospital. During this time I became interested in the phenomenon of ischaemic preconditioning which led to a very enjoyable 2 year American Heart Fellowship in the lovely town of Boston, USA with the late Carl Apstein. I returned from the USA in 1994 to work with Dr Pamela Garlick investigating the metabolic basis of preconditioning using NMR spectroscopy before eventually taking up a lectureship position with Ajay Shah in 1998, this time south of the river, at the Denmark Hill Campus of King’s College. My research interests are now split between the role of reactive oxygen species, specifically those derived from the NADPH oxidase in the development of cardiac hypertrophy/diabetic cardiomyopathy and the mechanisms underlying contractile dysfunction in septic shock.
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