Dr Lissette Sanchez-Aranguren
Translational Medicine Research Group
Aston Medical School
My research focuses on understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for potential drug intervention in diverse areas of human disease. My passion to understand metabolic routes, linking mitochondrial bioenergetics and oxidative stress, began during my PhD studies where I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia.
Currently, I am part of the Translational Medicine Research Group at Aston Medical School. My lab aims to explore the role of mitochondria in regulating hydrogen sulphide metabolism and understanding its impact on cardiovascular health whilst exploring the development of novel nanoparticle formulations to enhance the delivery of molecules to the mitochondria.
Selected recent publications:
- Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gels Formulations for the Treatment of Impaired Vascular Function: an Ex Vivo Study (In press)
- MZe786 Rescues Cardiac Mitochondrial Activity in High sFlt-1 and Low HO-1 Environment. https://pubmed.ncbi.nlm.nih.gov/32660064/
- MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment. https://doi.org/10.1016/j.redox.2020.101768